Biotechnology Biotransformations I, Volume 8a, Second Edition

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1998 | 606 Pages | ISBN: 3527283188 | PDF | 17 MB
Biotransformations have developed into an important tool of organic synthesis. Most synthetic sequences will benefit from the use of a biotransformation step, and the use of multiple enzyme single pot reactions enables several steps to be telescoped together. Volumes 8a and b provide a comprehensive guide to the established and emerging uses of enzymes. Each chapter is devoted to a single class of transformation so that the competing possibilities can be readily compared, and there is a strong emphasis on practical and reliable reactions. Topics included in Volume 8a are: Perspectives/ Practical Aspects/ Lipases/ Esterases/ Cleavage of Amide Bonds/ Nitriles/ Alkaloids/ Yeast/ Alcohol Dehydrogenases/ Hydroxylation and Dihydroxylation/ Flavin Monooxygenases Major topics of Volume 8b: Phosphorylation/ C-C Bond Formation/ Formation of Glycoside Bonds/ Synthetic ApplicationsContent: Chapter 1 Perspectives in Biotransformations (pages 5-23): Michael K. TurnerChapter 2 Biotransformations?Practical Aspects (pages 25-34): David R. KellyChapter 3 Biotransformations with Lipases (pages 36-191): Romas J. Kazlauskas and Uwe T. BornscheuerChapter 4 Esterases (pages 193-241): Sara J. PhythianChapter 5 Cleavage and Formation of Amide Bonds (pages 243-275): David W. T. HoopleChapter 6 Nitriles (pages 277-324): Alan William BunchChapter 7 Alkaloids (pages 326-361): Neil C. BruceChapter 8 Yeast (pages 363-389): Stefano ServiChapter 9 Dehydrogenases?Characteristics, Design of Reaction Conditions, and Applications (pages 391-473): Jorg PetersChapter 10 Hydroxylation and Dihydroxylation (pages 475-533): Herbert L. HollandChapter 11 Flavin Monooxygenases-Uses as Catalysts for Baeyer?Villiger Ring Expansion and Heteroatom Oxidation (pages 535-587): David R. Kelly, Peter W. H. Wan and Jenny Tang



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