Vaccinology Principles and Practice

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2012 | 539 Pages | ISBN: 1405185740 | PDF | 16 MB
Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human applicationIncludes evaluation of vaccine efficacy and safetyDetails clinical trial design, including regulatory requirementsDiscusses the emerging field of active cellular immunotherapyVaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.Content: Chapter 1 Concept and Scope of Modern Vaccines (pages 1-11): D. Huw Davies, Clint S. Schmidt and Nadeem A. SheikhChapter 2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants (pages 13-28): Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel?van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter and Volker GerdtsChapter 3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules (pages 29-46): Antony N. Antoniou, Izabela Lenart, David B. Guiliano and Simon J. PowisChapter 4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design (pages 47-60): Janine Bilsborough and Joanne L. VineyChapter 5 Immunologic Memory: T Cells in Humans (pages 61-78): Maria Candela Iglesias, Victor Appay and Arnaud MorisChapter 6 Immunologic Memory: B cells (pages 79-93): F. Eun?Hyung Lee and Inaki SanzChapter 7 Utility of Mouse Models in Vaccine Design and Development (pages 94-109): Catharine M. Bosio, Megan MacLeod, Philippa Marrack and Ross M. KedlChapter 8 Utility of Nonhuman Primate Models for Vaccines (pages 110-130): Preston A. Marx and Alexander F. VoevodinChapter 9 Sequence?Based Computational Approaches to Vaccine Discovery and Design (pages 131-149): Darrick CarterChapter 10 Antigen Discovery for Vaccines Using High?Throughput Proteomic Screening Technologies (pages 150-167): D. Huw DaviesChapter 11 Phage Libraries (pages 168-178): Aaron K. SatoChapter 12 Attenuated Bacterial Vaccines (pages 179-195): Richard W. Titball and Helen S. AtkinsChapter 13 Virus?Like Particles as Antigen Scaffolds (pages 196-208): Bryce Chackerian and John T. SchillerChapter 14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development (pages 209-223): Yper Hall and Miles W. CarrollChapter 15 Recombinant Adenoviruses for Vaccination (pages 224-236): Nelson Cesar Di Paolo, Dmitry Shayakhmetov and Andre LieberChapter 16 Recombinant Avipoxviruses (pages 237-254): Michael A. Skinner and Stephen M. LaidlawChapter 17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy (pages 255-274): Patrick Guirnalda, Laurence Wood, Matthew Seavey and Yvonne PatersonChapter 18 Nucleic Acid Vaccination (pages 275-285): Britta Wahren and Margaret A. LiuChapter 19 Artificial Antigen?Presenting Cells: Large Multivalent Immunogens (pages 286-299): Matthew F. Mescher and Julie M. CurtsingerChapter 20 Transcutaneous Immunization via Vaccine Patch Delivery System (pages 301-323): Robert C. Seid and Gregory M. GlennChapter 21 Needle?Free Jet Injection for Vaccine Administration (pages 324-335): Brian R. Sloat, Hoi K. Tran and Zhengrong CuiChapter 22 Oral Vaccines: An Old Need and Some New Possibilities (pages 336-347): Amit A. Lugade, Kalathil Suresh and Yasmin ThanavalaChapter 23 Adjuvants: From Serendipity to Rational Discovery (pages 348-360): Derek T. O'Hagan and Andreas WackChapter 24 Immunostimulatory Properties of Biodegradable Microparticles (pages 361-374): Fiona A. Sharp and Ed C. LavelleChapter 25 Co?Administration of Co?Stimulatory Moieties (pages 375-392): Carolina Arancibia?Carcamo and Yvette LatchmanChapter 26 Toll Receptors in Relation to Adjuvant Effects (pages 393-400): Dipshikha Chakravortty, Amit Lahiri and Priyanka DasChapter 27 Regulatory Issues (FDA and EMA) (pages 401-415): Murrium Ahmad, Victoria Byers and Peter WilsonChapter 28 Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine (pages 417-440): Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton and Camilla JandusChapter 29 Clinical Development Strategy: Nuts and Bolts (pages 441-451): Candida Fratazzi and Claudio CariniChapter 30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification (pages 452-463): Robert Rees, Stephanie Laversin, Cliff Murray and Graham BallChapter 31 Mass Immunization Strategies (pages 465-479): David L. Heymann, R. Bruce Aylward and Rudolf H. TangermannChapter 32 The Role of Mathematical Models in Vaccine Development and Public Health Decision Making (pages 480-508): Marie?Claude Boily, Marc Brisson, Benoit Masse and Roy M. AndersonChapter 33 Vaccine Safety (pages 509-524): John Iskander, Claudia Vellozzi, Jane Gidudu and Robert T. Chen



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